Download e-book Well-Differentiated Malignancies: New Perspectives

Free download. Book file PDF easily for everyone and every device. You can download and read online Well-Differentiated Malignancies: New Perspectives file PDF Book only if you are registered here. And also you can download or read online all Book PDF file that related with Well-Differentiated Malignancies: New Perspectives book. Happy reading Well-Differentiated Malignancies: New Perspectives Bookeveryone. Download file Free Book PDF Well-Differentiated Malignancies: New Perspectives at Complete PDF Library. This Book have some digital formats such us :paperbook, ebook, kindle, epub, fb2 and another formats. Here is The CompletePDF Book Library. It's free to register here to get Book file PDF Well-Differentiated Malignancies: New Perspectives Pocket Guide.

This Article Anticancer Research October vol. Classifications Series: Review Reviews. Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager. Current Issue September , 39 9. No SPIE account? Create an account Institutional Access:.

Biology and evolution of poorly differentiated neuroendocrine tumors

The alert successfully saved. The alert did not successfully save. Please try again later. Carson, "Intraoperative photoacoustic screening of breast cancer: a new perspective on malignancy visualization and surgical guidance," J. Citation Only. RIS Zotero. Ref Works.

Introduction

Single Year. Clear Form. The well differentiated type is less aggressive and tends to be a large painless mass found in deeper tissues and in the retroperitoneum. Myxoid, round cell and pleomorphic types tend to be in the arms and legs, whereas dedifferentiated tends to be in the retroperitoneum and often associated with the well differentiated variety. Specifically, pleomorphic liposarcoma is the least common subtype with a high rate of recurrence and poor outcomes.

References

The specific cause of liposarcoma is still unknown. Clinically, it can be first noticed particularly in the extremity in an area of recent trauma where the patient may find a mass, however the cause and effect are quite likely purely coincidental.

Liposarcoma generally is attributed to a change in some of the genes that are normally present in fat cells. A series of abnormalities in these genes mutations or DNA alterations can lead to malignant changes characterized by uncontrollable growth.

Classification of Endometrial Carcinoma: New Perspectives Be : Advances in Anatomic Pathology

Liposarcoma is a soft tissue sarcoma, affecting approximately individuals each year in the United States. It affects men more than women, and more specifically middle-aged men ranging from 50 — 65 years of age. Children are rarely diagnosed, but when liposarcoma does occur in children, it is usually during adolescence.

There is no specific ethnicity in which liposarcoma is more common. Certain risk factors have been shown to predispose individuals to developing soft tissue sarcomas, such as liposarcoma, including: prior radiation, familial cancer syndromes, damage to the lymph system, and long term exposure to certain toxic chemicals such as vinyl chloride, a chemical used to make plastic.

There are other diseases that can present very similarly to liposarcoma.

Nuances in Well Differentiated Thyroid Carcinoma

Lipoma is a non-cancerous benign tumor that can look similar to liposarcoma but it is usually softer and feels like a mass directly below the skin rather than in deeper parts of the body. A lipoma cannot transform into a liposarcoma. Other soft tissue tumors, such as undifferentiated pleomorphic sarcoma, lipomatous hemangiopericytoma, non-lipogenic sarcoma and gastrointestinal stromal tumors, can also look similar to liposarcoma when initially evaluated under a microscope.

The most critical step in the diagnosis of liposarcoma involves taking a biopsy of the mass of concern. A biopsy is when tissue is retrieved from the tumor in order to be evaluated under the microscope to assess whether or not the tissue has tumor-specific features.

Since many of these tumors are deeply embedded into the body, imaging such as ultrasound can be used to guide where the needle is relative to the mass and ensure that the tissue sample is retrieved specifically from that mass.

Biology and evolution of poorly differentiated neuroendocrine tumors

Liposarcoma can also be diagnosed by imaging the body either by computed tomography CT or magnetic resonance imaging MRI. CT uses multiple X-ray measurements to create an image of the body and it is important in assessing the location of a mass and its relationship to surrounding tissues.

MRI is another way to image liposarcoma and it can show characteristics of the mass itself which might be helpful in diagnostic differences between benign and malignant soft tissue masses. Treatment Therapy to treat liposarcoma largely depends on the type, size and location of the tumor. Surgery is a favored option compared to others, but there are certain cases where it would be riskier to attempt to remove the tumor surgically.

How cancers are graded

For example, this can occur if it is located in the retroperitoneum where it is deeply embedded and involves multiple organs. Another example would be if the tumor were adjacent to vital structures, such as major blood vessels, where removing the tumor itself could pose a significant risk. If a tumor spreads in such a way that the mass cannot be completely removed with surgery, chemotherapy or radiation therapy can be considered to kill the rest of the tumor and reduce the risk of the cancer reoccurrence.